Research People and Projects Our primary goal in this mid-scale clinical trial is to test the hypothesis that clinicians who use the output of our mobile system to adjust buprenorphine and methadone dosing achieve…
African-American and other minority populations have been poorly represented in large-scale genomic studies, and yet these populations (i) have the largest disparities in health care and outcomes, and (ii) have…
The lateral hypothalamus houses a small population of neurons (~7000 in rats, ~50,000-80,000 in humans) that produce the neuropeptide orexin (also known as hypocretin). These orexin-producing neurons project broadly throughout…
Cardiovascular disease (CVD) is a major health concern facing the U.S. population, with the impact of risk factors accumulating over the lifespan and beginning well before older age. Increasingly, the study of cardiovascular health for people living with HIV is…
The purpose of this study is to determine how often and how much adolescents and young adults with Autism Spectrum Disorders (ASD) use alcohol and other drugs. Approximately 400 adolescents…
A large number of studies over the last 14 years show that orexin neurons play an important role in reward processing and drug abuse. Although these studies show that orexin-1…
We will apply novel HRMS methods on >3,200 stored plasma samples to construct amongst the largest cohort database with biologically-defined ART adherence and illicit drug use measures
Anxiety and anxiety-related disorders (AARD) are notable risk factors for alcohol use problems and their co-occurrence results in tremendous health costs and societal burden. Psychological treatments that integrate cognitive-behavioral therapy…
African American adults are disproportionately exposed to stressors, such as racial discrimination, that increase risk for problem drinking and are more likely than White adults to experience alcohol-related illness, injuries,…