Research People and Projects Having ascertained and clinically assessed over 65,000 participants (cases and controls) in the Genomic Psychiatry Cohort allows us the unique opportunity to study individuals with highly penetrant rare mutations that,…
With the majority of US states having adopted legislation to medically and/or recreationally legalize cannabis, public perception of the drug is now overwhelmingly favorable. Increased access and prevalence of use…
By 8th grade, one in five Black youth and one in four Latinx youth has tried some form of alcohol, nicotine, or cannabis – well after substance use related cognitions…
The goal is to examine the antecedents and health consequences of alcohol misuse from adolescence through early midlife (the 30s). There is a paucity of longitudinal studies on alcohol misuse…
A growing body of evidence indicates that environmental information can be inherited, which suggests that changes in the mammalian germline can act as a trans-generational carrier of environmental information. Here,…
Recent discoveries implicate specific genetic variants that confer extremely high risk for schizophrenia (SZ), a devastating psychiatric syndrome. The combination of genetic findings and technological advances are powerful tools for…
The objective in this project is to advance the understanding of the mechanisms through which parental divorce/separation and marital discord influence offspring alcohol use disorder (AUD) and related outcomes (e.g.,…
In the United States (U.S.), sexual minority men (SMM) are disproportionately affected by HIV compared to the general population. For this population, intersectional sexual minority and HIV-related stress add to general life stressors to…
If successful, this study will have uncovered a previously unknown biological indicator of how craving works to bias decisions toward drug use in addicted individuals
With this project we aim to provide an answer to why patients may become more tolerant of risk and uncertainty in periods preceding reuse and, in doing so, hope to…