Research People and Projects Our objective is to delineate the impact of a spouse’s substance use and psychiatric disorders on their partner’s alcohol use disorder (AUD) onset, remission, and relapse during marriage within a…
This project will use theory- and data-driven approaches to elucidate the neurocomputational mechanisms underlying heterogeneity in the symptoms of major depression
This project leverages recent advances in Bayesian machine learning to carefully delineate neurodevelopmental trajectories of substance use risk with specific consideration of the societal and individual effects of COVID-19 using…
Through secondary analysis on this data we will build deep, multilevel polygenic models of high-level traits, such as cognitive, affective and psychiatric traits.
Smoking cessation interventions that are effective in the general population have been minimally effective among people with an Opiate Use Disorder (OUD). Yet, smoking cessation is related to reduced drug…
Binge drinking (4+/5+ drinks/occasion for females/males) increases risk for preventable alcohol-related consequences, particularly among young adults (ages 18-25). As part of our NIAAA-funded Mechanisms of Alcohol Treatment Change (MATCH) text…
Little is known about the mechanisms that confer risk for antisocial behavior during adolescence, as previous studies have focused on small, non-representative samples, and further research to determine these mechanisms…
Having ascertained and clinically assessed over 65,000 participants (cases and controls) in the Genomic Psychiatry Cohort allows us the unique opportunity to study individuals with highly penetrant rare mutations that,…