Research People and Projects The goal of this work is to facilitate detailed behavioral characterization of the individual: a participant’s cognitive computational phenotype and clinical mental health symptom phenotype, and to map these dimensions…
While substance problems and associated externalizing behaviors (i.e., violence, delinquency) have a significant negative impact on health and development, empirically-supported treatments are time- and resource-intensive, placing a high burden on…
The 3q29 deletion is associated with a high risk of neurodevelopmental and neuropsychiatric disorders. We propose to use a novel approach to investigate the function of genes in the 3q29…
The proposed longitudinal, observational study will use highly rigorous methodology to determine the associations of sleep and proxy measures of circadian rhythms with non-medical opioid use among individuals in opioid…
This project brings together expertise in neuroscience, genetics, neuroimaging, computational psychiatry, digital phenotyping, and clinical research to collect preliminary data to create an integrated approach to developing more targeted treatments…
Understanding what the brain treats as costly will lay the foundation for future work on the nature of subjective effort, and suggest target mechanisms for promoting desirable cognitive effort.
This project will test the hypothesis that the cortical excitatory-inhibitory balance regulates how closely to a critical state the brain operates, and thereby how sensitive people are to effort costs.…
Patient-centered opioid tapering might be facilitated by behavioral interventions that address the factors driving the downward spiral from chronic pain to opioid misuse. The overarching goal of this proposal is…
This I-Corps project is based on the development of a pharmacological adjuvant that limits the abuse liability of stimulant medications. The proposed technology may be used to develop a new…